Modern Music :: essays research papers

Music has been around for a great many years. The stone age man had initially begun some sort of sounds in which fan out into the music that we tune in to today. This ancient music was begun by the stone age men with the end goal for them to communicate, and the other people who listened were influenced similarly that individuals are influenced by music today. For instance, on the off chance that somebody is vexed they will tune in to something that will show signs of improvement temperament, maybe something smooth or delicate. In the event that they are glad, they will tune in to something that is increasingly enthusiastic, etc. After I talked with four individuals - loved ones - I discovered what kind of music they tuned in to when they are disturbed, furious, or quiet. Music contacts people’s spirits, and gets the best or most exceedingly awful out of them. My companion Kyle stated, â€Å"When I am feeling awful I tune in to fundamentally rap since it gets me advertised up to where I need to move. Rap lets me show signs of improvement disposition where I can overlook the issue or what I was frantic at before.† He proceeds, â€Å"No other music influences me as much as rap does in light of the fact that rappers put all that they have into their melodies, yet that is just my opinion.† Kyle has tuned in to rap since he was 13, and he really got me intrigued into it. I never loved rap until I began to spend time with him, and I am currently beginning to appreciate it due to its’ assorted variety that is associated with making the music. Every rapper has their own rendition of the world, and they express it through their music. - 2- Not all rap music is acceptable as indicated by a Texas widow, who documented a claim against Tupac Shakur. Her better half, a Texas state trooper, was supposedly shot to death by a man who took a vehicle. In the man’s vehicle a Tupac tape was found in the tape player, and Tupac’s music was purportedly to fault (Damean). A few people will in general pay attention to music as well, and wind up committing errors, and they need to endure the results like that Texas man. Those individuals, who pay attention to the music as well, are not steady, and the music draws out the most exceedingly terrible of them. Then again, individuals like Kyle have no issue with a portion of the verses that a few rappers fuse into their music, and end living cheerfully with society.

Bless You and Various School Activities Essay

We have assembled here today to say goodbye to the understudies of standard tenth. I am without a doubt respected to be allowed this chance to speak to the understudies of standard ninth. Exactly when we begin to get settled with an individual, something comes to modify the formula. In this specific situation, I might want to make reference to that for as long as not many months, the understudies of principles ninth and tenth have surely worked intently together to arrange different school exercises which has helped us manufacture close ties of companionship. Furthermore, presently, before we know, its opportunity to state ‘Adieu’. The Bible says â€Å"To everything there is a reasonand an opportunity to each reason under heaven† May I venture to offer you a bit of guidance? Life is arrangement of occasions, both great and awful. Regardless of how deft your hierarchical aptitudes, there will consistently be life impacting factors over which you may have no control. As you leave on this new phase of life, you will have the option to ascend to the occassion in view of the qualities our school has instructed you. On such occassions consider standards our instructors have imparted in you and do right by us. â€Å"Change without a doubt is difficult, yet over needfull†, said Thomas Carlyle. We are going to miss you without a doubt. We implore that God direct you and watchman you, as you embrace this new and energizing excursion of lifem in eleventh science. A generally excellent night to all the regarded dignitaries, instructors, my dazzling seniors and companions, I Yashodhar of M. E VI sem am lowered and regarded to have the chance to say goodbye to you from your youngsters. For the benefit of my group, I need to compliment all of you on your triumphs at Global Institute Of Technology and Management. It appears not more than a day or two ago when we were all discussing our senior’s goodbye as they proceed onward. I believed that it is difficult to bid farewell †¦ and I was correct †it is hard. However I see myself as lucky to have met such an uncommon individual †¦ an individual that we care such a great amount about †¦ that it makes bidding farewell to them hard! As we bid farewell, we advise ourselves that goodbyes are not always, nor are they the end. They are basically words to state that we will miss you profoundly and that we will recall you affectionately. I despite everything recollect the day when I initially met my seniors and to come clean I was truly alarmed by those sweet amusing things which they caused me and my class colleagues to do. In any case, later we as a whole understood that it was simply to expand our certainty level and to diminish the correspondence hole among us. Furthermore, I trust this is a serious guide to exhibit their well wishes for us. In spite of the fact that we might be isolated by time and separation in the meantime, nothing will lessen the significant job that you have and consistently will play in our lives. We wish you glad undertakings, incredible new kinships, stunning encounters and a mind-blowing excursion. An amazing majority is a progression of pictures. They pass us by like towns on the parkway. However, in some cases, a second shocks us as it occurs. What's more, we realize that right now is in excess of a transient picture. We realize that this moment†¦ all aspects of it†¦ we will live on until the end of time. At long last I might want to state that any place you go you will stay nearer to our souls. Also, May you vanquish new fronts throughout everyday life. May God favor you with a cheerful fruitful life and I.. We have accumulated here today to say goodbye to the understudies of standard tenth. I am in fact regarded to be allowed this chance to speak to the understudies of standard ninth. Exactly when we begin to get settled with an individual, something comes to change the formula. In this unique circumstance, I might want to make reference to that for as long as hardly any months, the understudies of norms ninth and tenth have in fact worked intently together to sort out different school exercises which has helped us manufacture close ties of kinship. Furthermore, presently, before we know, its opportunity to state ‘Adieu’. The Bible says â€Å"To everything there is a reasonand an opportunity to each reason under heaven† May I venture to offer you a bit of guidance? Life is arrangement of occasions, both great and terrible. Regardless of how deft your authoritative abilities, there will consistently be life affecting variables over which you may have no control. As you set out on this new phase of life, you will have the option to ascend to the occassion as a result of the qualities our school has educated you. On such occassions consider standards our instructors have ingrained in you and do right by us. â€Å"Change to be sure is excruciating, yet over needfull†, said Thomas Carlyle. We are going to miss you without a doubt. We ask that God direct you and gatekeeper you, as you embrace this new and energizing excursion of lifem in eleventh science. A generally excellent night to all the regarded dignitaries, instructors, my dazzling seniors and companions, I Yashodhar of M. E VI sem am lowered and regarded to have the chance to say goodbye to you from your youngsters. In the interest of my group, I need to praise all of you on your triumphs at Global Institute Of Technology ; Management. It appears only a few days ago when we were all discussing our senior’s goodbye as they proceed onward. I felt that it is difficult to bid farewell †¦ and I was correct †it is hard. However I view myself as blessed to have met such an uncommon individual †¦ an individual that we care such a great amount about †¦ that it makes bidding farewell to them hard! As we bid farewell, we advise ourselves that goodbyes are not perpetually, nor are they the end. They are essentially words to state that we will miss you sincerely and that we will recollect you affectionately. I despite everything recall the day when I initially met my seniors and to come clean I was truly unnerved by those sweet interesting things which they caused me and my class colleagues to do. However, later we as a whole understood that it was simply to expand our certainty level and to diminish the correspondence hole among us. Furthermore, I trust this is a serious guide to show their well wishes for us. In spite of the fact that we might be isolated by time and separation in the meantime, nothing will lessen the significant job that you have and consistently will play in our lives. We wish you upbeat undertakings, awesome new kinships, stunning encounters and an amazing excursion. A large portion of our life is a progression of pictures. They pass us by like towns on the expressway. In any case, once in a while, a second staggers us as it occurs. What's more, we realize that right now is in excess of a passing picture. We realize that this moment†¦ all aspects of it†¦ we will live on for eternity. At long last I might want to state that any place you go you will stay nearer to our souls. Furthermore, May you vanquish new fronts throughout everyday life. May God favor you with a cheerful fruitful life and I..

Tuition fees to hit language courses

Tuition fees to hit language courses The OE Blog Further threats to university survival have emerged as a knock-on effect of the government’s scheme to raise tuition fees in England to £9000, as it has become clear that many language courses may have to be discontinued. Universities have pointed out that with the extra year abroad taken as part of most language courses, students would be required to pay up to £36,000 for their degree, a step many may not be willing to take. Language Courses will cost more With rocketing fees, the price of courses will be far more important than ever before in determining a student’s choice of university and subject, and the University Council for Modern Languages believes subjects such as French, Spanish and German simply will not be able to compete with shorter, cheaper courses. Where before a student may well have been willing to pay the relatively modest £3000 sum for the benefits and cultural opportunities of an extra year’s study abroad, it is thought that now, with the price trebled and the interest rate raised, the prospect will be hugely off-putting to prospective students. Plea for Government Fee Waiver The University Council for Modern Languages, chaired by Professor James Coleman, has written to the government via Universities Minister David Willetts to request an urgent waiver of fees for language students for the year they spend studying abroad. The government has responded by ordering a review of support for the subjects, with the Higher Education Funding Council for England undertaking a study of what extra support may be necessary, but these findings will not be published until the autumn, potentially leaving hundreds of thousands of perspective students in the dark about funding as they try to make choices for their university applications later this year. Impact on Universities Coleman foresees a devastating impact on the numbers of applicants for modern language courses as a result, and has urged that “The government urgently needs to make a statement that they will support a year abroad and to moderate the impact of higher fees.” Other institutions are more pessimistic the University of the West of England has already taken steps towards a decision to stop providing all language courses altogether. But the issue doesn’t end there. Even should the government choose to rescue language courses by allocating extra funding to cover the year abroad, there will be a multitude of courses ready to follow suit with similar problems. And they will not all be lucky enough to be allocated extra support. Courses as diverse as architecture, engineering, medicine, veterinary science and biochemistry all involve extra years of study on top of the standard 3 year degree course, and all stand to suffer from the same disadvantage. Furthermore, there are many other courses, like chemistry at Bristol University, where a year’s extra study abroad is included and encouraged as an opportunity to broaden students’ horizons and introduce them to entirely new fields of learning and exploration. Some of the more mainstream courses may be lucky enough to obtain a government waiver, but with most universities heading for £9000 fees and the government budget for student loans stretched precariously thin, it is likely that many will be left to suffer the consequences unaided. Potential Outcomes So what will be the impact of this squeeze on four year courses? There are several possibilities. The first is that the fallout may not be as serious as universities fear- with hundreds of thousands of applicants not managing to gain a place at any university last year, it is possible that the demand for available places will remain high enough to sustain these courses in spite of their sky-high price tags. Or perhaps these courses, reputed to be less competitive due to their higher cost, will become the vestige of the academically challenged upper class private school graduates whose parents are willing to pay any cost to make sure they get in somewhere. This could result in the sort of two-tier class education system feared by many activists protesting agains the rising tuition fees. Another possibility is that the universities themselves will have to cover the cost â€" Essex University has already announced plans to fund a fee waiver for the year abroad out of its own pocket. But given the huge cuts to university and teaching budgets this would inevitably result in losses and down-grading elsewhere. The problem may result in many universities simply withdrawing the year abroad from the course altogether, or offering it as an optional but not compulsory extra. There are many who would welcome this development as a financially sensible curtailment of an unnecessary and frivolous opportunity for students to abandon their studies and gallivant abroad â€" it is no accident that the extra year is nicknamed a “year out”. But they are short-sighted. To complete a three year language degree without spending a substantial period of time immersed in the culture and dialect of the country one is studying is like learning medicine without ever setting foot in the dissection lab. The quality and academic strength of our language graduates will suffer as a result. In the same way, across the board, as ‘non-essential’ subjects like arts, cultural and non-vocational courses are sacrificed to the brutality of these cuts, England will feel the impact and suffer their loss most severely in the long term.

ANALYSIS THE ROLE OF HONDA AND HONDA KINETIC - Free Essay Example

Sample details Pages: 16 Words: 4932 Downloads: 7 Date added: 2017/06/26 Category Marketing Essay Type Case study Did you like this example? 1. Globaliztion international trade theories Explain Globalization is the process of creating relationships, interactions and integrate among the economies, societies, cultures, people, companies, and government of the different countries, a process driven by international trade and investment support by information technology. This process is influence on environment, on cultures, on economic development, international trade and human well being in the around world. Don’t waste time! Our writers will create an original "ANALYSIS THE ROLE OF HONDA AND HONDA KINETIC" essay for you Create order As result of the globalization changes came into effect in various aspects; Economic (international trades) Political Cultural Industrial Financial markets Heath sectors Information Language Competition Ecological changes According the above mentioned areas, the concept globalization is help to develop different areas. But, as a result of globalization negative effects are Influence on Economic liberation by different nations and unions. Brain drain Most of intelligent people move around the world without remaining mother countries. Such as Business managers, Doctors, Engineers and Scientist, etc. Common Disease Spreading the disease across the world than the past. Financial Crisis global financial crisis will make more impact on the different economies. Ex. Economic down turn in USA made huge impact on the all over the world. Increase income disparity among the different countries. and create multicultural impact Illicit trading and increased breaking international and country laws will. When it further analyzed globalization Famous writer Peter Dickens says about the globalization the following manner; A qualitatively different process in which there is a functional integration of internationally dispersed activities (Global Shift) The Global Shift book was explained two type of concept which is related in each other. Those are; Internationalization Globalization Further he explained following changes in his books Extension of production chains across national boundaries Pattern of foreign direct investment (FDI) The creation of supranational organizations Technology acting as engine of economic transformation The development of unit of enterprise through the spending of multinational enterprises. The impact of the particular industries on transferring cultures, lifestyles and personnel across national boundaries. Therefore we can be concluded; As a result of globa lization ,the governments and individuals in the industrialized nations increased growth potential capacity in globalize economy Government policies more focus towards to the economic development, stable of the economy ,increasing the employment, reduce social inequality, social fairness and promotion of small firms, increased harnessing of innovative technologies and attracting foreign investment Always make difference in incomes and living standards within the different nations. Practices and standardization of global governance more and more influenced on global businesses authorities. Different professional bodies influence on the different areas and bring more concepts widening scope the subject. Ex CIMA, AMA, CIM they changing their subjects to adapt globalization concept. Increased unemployment among the people the unskilled, poorly educated. Need more and more multi skilled people to manage the different haphazard and environmental changes effect on the bus iness. Effect of globalization is that creating an international trading opportunities as well as disadvantage for all the countries in the world. As result of dealing in international trade business, different theories and concept have been developed by different expertise. Among those most popular theories are; Mercantilism theory This theory mainly highlighted nations should have accumulated financial wealth in the form of gold, by encouraging export and discouraging imports. That is defined as mercantilism. Mercantilism theory is portrait other measures of the countries in relation to international trade. The following criteria considered as irrelevant to determine trading capacity of the nations or country. Well being, living standard and human development. This theory was applied by UK, Netherlands, and France during 1500 and 1700. Those countries practiced zero sum game (means that world wealth was limited and that countries only could increase their share at expenses of neighbors). In mercantilism countries economic development was prevented because of stopped import inside to country. Absolute advantage theory This theory was developed by Adam smith who highlighted that any country has an absolute advantage produces greater out put of good or service than other countries using the same amount of resources. Further Adam Smith is highlighted there should not be international trade restrictions such as quotas and tariff to prevent the international trade and it is essential flow goods and services according market forces. Absolute advantage theory contradicts against to mercantilism theory. Problem with this theory is that if there is not any absolute advantage with a country, international trade might be happen. Comparative advantage This theory was introduced by David Recardo in 1817.This is an ideal concept that is can apply for international trade and to develop international trade policies. Therefore this very important theory if any nations entering into the international trade. Here main principles that highlighted in comparative advantage are country should specialized in producing and exporting the products in which is has comparative or relative cost advantage compared with other countries and should import those goods in which is it has comparative disadvantage. Out of such specialization country could gain the greater benefit by applying that. Here mainly take into considered opportunity cost and specialization (maximum out put with limited resource). For instance Japan is highly specialized in producing car because of they are very good technology, required resources. But the Japan could not have capacity to produce TEA, there not specialized in that sector. On the other hand Sri Lanka is not having capacity to produce cars but they can produce TEA, they specialized in that area. Therefore we can see that, both country is specialized two different sectors by using those core competencies better this exp ort those products based on that specialization. Product life cycle theory 1960 Raymond Vernon developed this theory called international product life cycle theory. Under this is stressed that, a company will begin to export its products and take foreign direct investment as the products move through its life cycle. As an example in the mother country product is in the decline therefore, they could not generate sales and profit as earlier. At that time they are looking for another market to introduce that product to sustain in that business. That market is most probably international market. Porter diamond theory This is introduced by Michel Porter and He highlighted that competitive advantage in the aspect of clusters of industry based where the competitiveness of one company is related to the performance of the companies and other factors such as valued additions in value chain, customer relationship. To get finalized this used coulters of successful industries in 10 impor tant trading nations. Here porter shows that six broad factors incorporated with this theory. Those are; Considering areas Comment Factor conditions Human resources, physical resources, knowledge resources, capital resources and infrastructure. Specialized resources are often specific for an industry and important for its competitiveness. Those specific resources can be created to compensate for factor disadvantage. Diamond conditions in the domestic market can help create a competitive advantage, when there is sophisticated home market buyers pressure firms to innovate faster and encouraging create more advanced products that those of competitors Related and supporting industries Under this factor related and supporting industries are producing inputs which are important for innovation and internationalization .These industries provide cost effective inputs as well as participate upgrading process which they are using in currently. Thus stimulating other companies in the chain to innovate. Firms strategy, structure and rivalry Firms strategy, structure and rivalry constitutes fourth determinant of competitiveness. The ways, in which companies are generated or created, set goals and monitoring is important for the success. But the intensity of rivalry creating pressure and innovations to face competition. Government can influence Government can influence or support each of the four determinants of competitiveness. In clearly government can influence supply condition of key production factors, demand conditions in the market and competition between firms. As well as government can intervention at local, regional, national or supranational. Chance Events that are occur in the outside of control of a firm. They are important because they are creating discontinuities in which some gain competitive positions and some lose. This theory is plays an important role in the analysis of modern international trade in terms of nations competitiveness. Here the major examples are Coca cola, Standard chartered, Uniliver and Nestles few of companies which are showing nations competitive advantage. 1.2. Benefit and challenges of globalization As a result of globalization the following major benefits are gained by Honda; Entering into new markets As result of globalization different economies are open to the other countries products. That leads entering into new market. Increasing their sales another benefit that is can gain help to increase their sale. Thats leading to increase the profitability of the business. Tax benefit some of the countries are giving tax free benefits, tax holidays, and tax exemptions to promote foreign direct investment. That is helping to increase the company stake and profitability of the country. Opportunity to gain cost advantage In the country like India and china, labor cost is very law. As result of that cost of production can minimize and help to increase profitability also. Help to develop strategic alliances such as joint ventures, mergers, acquisitions, takeovers and tide up agreement, management contract, joint promotion and mega marketing campaign. Which are helpi ng to increase the brand awareness and brand visibility of the in that particular country or region. The following challenges will face by Honda in the global economy Overriding agreement in this case Honda company play dominating role, they have override firodias agreement when entering into Indian market. As a result of that emerged conflict between two parties and both parties suffer due to that agreement. Effect of different risk. The following major risk can be identified via that; Cultural risk Once reach global market is approached will face different cultural barriers. As an example of in India is different cultures and different languages within the countries, as well as way of thinking and attitude is totally different compare to other countries therefore Effect of changes in exchange rate This very crucial factor is in the international business. Effect of exchange rate is directly affected on the profitability of the company as well as creating loss on company. Because of money appreciation and depreciation derived by economic activities like import and export. Threat from natural environmental risk Some of natural environment effects are making huge impact business. Cyclones, heavy raining, flood, snow are directly affected on plant operations and product distribution. Not only that, it is created huge losses on any company. For instance flood and cyclones are making heavy effect on the business operations. Even those cases cannot insure to manage that risk. Changes in Interest rate risk Interest rate makes huge impact on cost borrowings. This is directly affected on financial cost of business and profitability. As well as, it will make impact on the cost of material and components ultimately that will leads to reduce the profitability and raise the price of the product. Labour turnover rate Highly trained or experience staff might acquired by competitors by giving high salaries as well attractive benefit. This issue directly affect on plant operations, raising new staff training and development. Trade secret and leakage of information There risk to leak trade secrets and top importance information (financial and non financial) which are directly influence on decision making and operational activities of business. Such information leakages strengthen competitors. It is very good opportunity for them attack on weaker areas. Some situations if the Inland Revenue get to know about that information, tax issues will are begun. Threats from competitors If competitions is goes up that effect on the company market share and profitability of the company. Behaviour of Employees Negligence, Omissions, fraud, judgmental errors, less knowledge of operations and decisions making might create high risky situations where create huge loses, impact on reputations and loosing the customers. 1.3. Assessing theoretical frame work for international of international trade and globalization in terms of a supporting organizational structure may Honda employing Most suitable theoretical framework work for Honda is application of the porter diamond theory. In case highlighted Considering areas Analysis Factor conditions Human resources, physical resources, knowledge resources, capital resources and infrastructure are having honda in their business Ex. Technical Know how and brand resources. Diamond conditions Sophisticated home market buyers pressure firms to innovate faster and encouraging create more advanced products that those of competitors. Ex Toyota and Nissan bigger competitors which they influence on the buyers behaviors. Related and supporting industries Provide cost effective inputs Ex. low cost metals supplied by suppliers to produce bike and cars. Firms strategy, structure and rivalry Intensity of rivalry creating pressure and innovations to face competition. Ex. Firoid company applies different marketing strategies to protect their home market and increase the sales. Ex Dealer awareness program and door to door campaign. Government can influence Government intervention has significantly involved protecting Firoid company when changes happen in the agreement. Chance Events that are occur in the outside of control of a firm. They are important because they are creating discontinuities in which some gain competitive positions and some lose. 2. Analyzing the Honda internal and external environment and make recommendation to achieve the organizational goals PESTEEL Factors Comment Political environment This would be totally change; No of political parties and their leaders philosophy towards economic development. How extent interfere the international problems. Ex.USA involvement very high as world powerful country. Not only that government grants, capital allowance, tax releases can be done by government base on the level of indutry. Political risk analysis Changes political environment is directly affect on the key strategic decision of the business. Role of the government and supporting for the business is depending on economic policy and foreign trade policy and relationship with the external countries. Under this are need to carry out the following analysis .Each country where Honda is operating need to analyze political risk and government changes, support and contribution auto making industry. Here this analysis help the following areas; Nationalization once political party has changed, they might be look their local products as well as more close and frie ndly countries investment and their business keep up their relationships. Taxation policy Every budgeting reporting period tax such as corporate tax, VAT capital allowances, etc. Economic environment It is describing economic style of the country, market free, or closes economy and mixed economy. On the basis of those economic the following areas will be changes. International trade policy Contribution of different section for GDP and GNP. Banking Finance market. (Exchange rate) Business cycles Need to look, whether there is economic depression or boom to decrease or expand production of the companies. Regulation on tax and layers of tax. Inflation in the economy ex. developing countries is having unpredictable inflation rate. Interest rate and foreign exchange totally changed automobiles cost of production and prices Consumer behavioral difference (such as decision making, response on promotion and advertising) Demand pattern is totally depending on the disposable income of the peoples for automobile sector. Market size growth (Country like India size and growth is very high for auto mobiles, specially for bike in low income segment ) Social environment Peoples diversity would be totally different according to the following factors Education (Highly developed countries peoples education makes difference among the people than developing courtiers. Language Culture norms experiences Motivation Risk taking attitude Technological environment Technological environment has made huge effect on auto mobiles industry. That has produced several advance featuring vehicles such as hybrid vehicles, solar power using vehicles, High security system integrated vehicles, automatically driven vehicles, new piston and engines are producing all the industry players to face competition. As well as technological environment creating new distribution channels such as make an online ordering for car, new technological application for motor vehicle assembling or develops user friendly features. Ecological environment Auto mobile business is making huge impact on physical environment; those are Air pollution Carbon emissions, Gas emissions and the other harmful air is released when driving auto mobile. Therefore to reduce those types of effects, some countries have applied different tax. Sound pollution This is another effects that happening in that environment. In the developing countries and developed countries millions of vehicles are pressing horn butut. That is creating huge sound effect during the traffic jam. Now trend is producing eco friendly bikes. As a result of those changes that is emerging sound of environment protection organizations. s well as they try to take legal action against company to protect environment. Legal environment Tax regulations Any economy is having different taxes for their development. Such as Income taxes Corporate taxes Social protection taxes Port Airport levy Corporate law These might be totally changed at the above mentioned levels. effected for companies Public law Public laws are also making difference at the above levels. Ex. Consumer protections rules and regulations, sales of goods and service, insurance law are highly creating impact on the automobile industry. Customs regulation Same as the above. Different nationals, as well as EU also and Globally custom rules and regulation are totally different Employee laws It is totally difference country to country and EU level as well as global level. Shipping rules regulations The following regulations apply for seaport security. Port Layout and design Passenger separation Staff background checking Staff screening Theses practice cannot be seen at all the international ship orts. Supply chains regulations Global level much more concern about those regulations; Distribution of goods Secure warehousing of goods From the warehouse and airside retail store. Staff security and stock control Description of diversity Strategic Implication Diversity of the market, brands and competitors Develop marketing intelligence system Analyze regular changes in the market and brand , market players Develop the firms strategies to reinforce the market share to beat companies by using marketing mix (7ps) Economic environment changes Scanning economic environment. Developing EIS (economic information system) Predicting changes in the economic environment. Listing to and hear expert opinions regarding future economic diversification. Social environment changes Analyzing the different countries Education, Language, Culture, education, experiences, Motivation towards to works, risk taking attitudes towards works. Review HR policies based on those regional differences. Implement develop strategies and review the strategies to evaluate whether it best fit with that region peoples diversification. Political environment changes Analyzing the different countries political parties and their policie s towards economic, business, education, health, legislation, etc. Analyze who and which parties will come to power. Develop strategy based that changes Additional areas need to be analyzes by the Kinetic Honda Company financial position This can analyze via balance sheet. by looking at financial position of the company can be determined level of short term and long term liquidity, gearing level, efficiency of capital employed, etc. This is very important for the company in terms of marinating stability. Industry cost structure Industry cost structure is help to determine the cost of the production, pricing policy, marketing investment and new product developments. Not only FIRODIAShas to identify future emerging cost and their adverse effects to develop cost minimizing strategies, while maintaining substantial level profit. Contributors of Company capital and return One of the most important sides is capital structure that drives dividend policy, profit retention rate and new expansion, power of creditors in businesses, level of capital investment in business. Owners of capital expecting substantial return on the business as well company expect to expand business future; these two objectives are clashing each other. This must be care fully analyzed to minimize interest gaps. Competitors activities This also making huge impact on the FIRODIASbusiness, if the competitors carry out mega promotion or produce fuel efficient and sophisticated featured car make huge impact competing segment. Competitors tried create barriers to prevent new market opportunities by using merging and takeover strategies. On the other hand they try to attack existing distribution channels by using different strategies. Cost of capital Return On Investment To create sustainable business growth and substantial return to investors as well company itself need to analyse cost of capital As well as firms can apply tools of five forces analysis to get analysed firms strength and weakness. Those 5 forces are; Analysis of the five forces effect on FIRODIAS Threat of new entrants new entrants determinant factors are; Economic of scale Car industry is having high fixed cost to recover need do high sales volume which means high BEP. FIRODIAS is a one of big player market where they can gain high economies of scale comparing other players. Those main reasons are; Technology that they using Level of market segment Business experience Distribution channel efficiency Productivity of labor New entrants cant afford the high fixed cost at the initial stage therefore very limited chance to enter into car market. Wider range of brands Different market segment covered by FIRODIAS by offering different brand, Which is creating entry barriers to another player. Only that they can gain niche market opportunities. Channel Converge FIRODIAS has already developed their distribution channel and having wider market coverage .In this situation also very low chance to take dealer choice for new players. To get their attention need to pay premium for distributors. High level of Capital investment Auto making industry major key driving factor is how much of amount is going to invest for this business. Especially, continuous R D need to keep customers with the business. If the existing player already acquired high volume of sales, very low potential to recover amount of capital invested in business via sales. Bargaining power of suppliers FIRODIAS is large auto maker of the industry; therefore FIRODIAS buy high volume of inputs (metals, irons, plastics, tires, electrics components) from suppliers. In this situation there is no high bargaining power for suppliers. Because of supplier sales and profitability might depending on this level sales.. Threat of substitute Major substitutes are; Cars Jeep Van Cab This is also making effect on GMs existing market. To minimize this threat FIRODIAS needs to go for that market segment. Bargaining power of customers Having Low have bargaining power of customers due to following reasons FIRODIAS has offered different variety of product range for the customer many choices. Different price level Prices are somewhat high other players compare to GM Product quality and safety is most important factor for car users FIRODIASis in the strong position The above reason create l very low potential to barraging for customer in existing car market. Rivalry amongst current competitors in the industry Rivalry amongst current competitors are Toyota, Honda, Benz, in the industry is determining factors are Cost structure market growth rate Production capacity Business environment uncertainties and exit barriers As per above mentioned factors FIRODIAS is in well secured position at the end of stage. This due to their major market driven campaign. 3. Analyzing soft and hard systems methodology Soft component In the soft component is considered as people and companies relationships. Such as culture, value, belief among the people. That is directly affected on to move forward company as whole or move backward. Hard component Hard component of the Company can be considered as method, production, process, 4. Analyzing and assessing the success of Honda business strategies Honda business strategy was to approach the Indian market by using the stake of Firodia Company.But that strategic alliances and joint agreements that they have developed was already failed, due to failure of the Firodia and their performance was not expected level therefore in that aspect they were failed. But ultimately Honda won the mortor cycle segment. 5 6. Discuss principle of corporate governance and ethics and assessing impact of corporate governance on Honda. The principles of corporate governance mainly concern was due financial crisis in the world and in the region. Poor corporate governance is turned business formidable and high risk level. As well as it is creating an effect on the whole economy of country. As an example, in USA Enron and worldcoms are the collapsed businesses due to poor corporate governance. Therefore principles of corporate governance is creating good environment for the companies to run the business very smoothly. The following major principle are apply for the corporate governance Principle 1: Performance Orientation This principle is highlighted that, objectives of any business emprise is to enhance economic value for all the share holders by using resources efficiently and effectively. A company that meets this shareholder value creation objective will have greater internally generated resources, improve forecasting environment, community and social obligations such pay taxes on time, reward, train and retain key staff as well as enhancing employee satisfaction. A key focus is is human capital strategy that is lead corporate success. Principle 2: Nomination and Compensation Committees A key success factor is the quality of leadership of an enterprise. A nomination committee with a written mandate and terms of reference consistent with good practice may ensure the selection of directors and a chief executive officer (CEO) of the highest caliber. Comprising mainly of independent directors, the committee should have a written definition of independence, inclusive of both subjective and objective criteria. A compensation committee should set the compensation policy for directors and senior management, commensurate with performance measured against comparable industry benchmarks and key performance Indicators such as economic value added. Principle 3: Disclosure To ensure transparency, companies annual reports should disclose true and fair accounting information prepared in accordance with applicable standards; consider substance over form in the presentation of accounts; disclose and discuss all material risks; disclose and explain the rationale for all material estimates; show manner of compliance, or explain deviations, if any, with applicable corporate governance codes; discuss goals, plans, and progress; and provide access to the register of shareholders showing beneficial ownership. In addition to annual disclosures, enterprises should comply with applicable continuous disclosure requirements. Disclosures should be timely and adequate to enable investors, third party analysts, or rating agencies to assess the quality of corporate governance and the true financial condition of the enterprise. Principle 4: Audit Committee 14. Audit committees with the following attributes are more effective: composed solely of independent directors, at least two of whom should have the requisite knowledge of accountancy, financial analysis, and financial reporting; at least one member should have a good understanding of the business of the enterprise; have a written mandate and terms of reference; engage only independent external auditors who should be answerable to the committee; and require that a suitable system of internal control and risk management is embedded into the fabric of the company; and focus on the substance of underlying transactions. Principle 5: Code of Conduct All enterprises must have a written code of business conduct and establish systems to ensure That it and all applicable laws are followed in letter and spirit. Principle 6: Conflicts of Interest Directors owe a fiduciary duty to the company that requires them to act in the best interest of the company. Actual and potential conflicts of interest should be identified, disclosed, and explained in sufficient detail to enable valid judgments to be made on their adverse impact. The persons who are conflicted should not participate in discussion and decision of the issue in question, nor be entitled to vote on any resolution where they are conflicted. Related party contracts should be disclosed in the annual report. Principle 7: Environmental and Social Commitment There is an inextricable relationship among the objectives of corporate performance, social development, and environmental protection. Enterprises, to be sustainable, will need to recognize and effectively deal with this triad of concerns, which, at times, may conflict with each other. Principle 8: Conduct of the Board of Directors Directors are expected to preserve and enhance shareholder value. Their effectiveness can be enhanced if they are legally empowered, have the requisite qualifications for the board committees on which they sit, make the needed time commitment, given the appropriate directorship training, are suitably compensated, receive proper notice of meetings, have the right to propose agenda items, consult each other privately in the absence of management and executive directors, and provided with appropriate information to enable them to perform their monitoring role and evaluate the performance of directors. They should be proactive and diligent. Principle 9: Responsibilities of Investors The pursuit of good corporate governance in investee enterprises is a risk management tool. Institutional investors, general partners, and fund managers have a fiduciary duty to actively monitor and vote on issues vital to the success of enterprises in which they invest as guardians of the savings entrusted to them. Enterprises will find it helpful to communicate with them, deliver in a timely manner true and fair disclosure reports, and remove impediments from voting by all shareholders by taking advantage of modern communications and follow a one-vote for one-share policy. The fair treatment of minority shareholders must be ensured and large institutional investors should lead the pursuit of shareholder rights Principle 10: The Role of Directors in Turnaround Situations Directors of troubled companies must play a proactive role in turnaround situations, but avoid preferential treatment of creditors, or trade when the company is insolvent. Recommendation Honda must follow the principle 9 responsible for the investors. Because of they have broken that principle. Honda had broken down principle of 6 (Conflicts of Interest).therefore they must follow that principles also As a ultimate conclusion Honda must follow the all corporate governance principles 7. Analyzing the implementation of organizational goals Working forces planning 50 teams has sent shop to shop and door to door Incorporating benchmark Kinetic has changed their credit policy Quality systems Improve mileage of scooters Budgeting mechanisms KEL increased their sales by 20% Marketing system Kinetic used agents to reach semi urban and rural areas. Ex reached Ghandinagar and Anhamdatbadh. Customer satisfaction camp. Brand promotional campaign arranged by Kinetic

Hip Hop Politics, Class Unity And The Internet - 1854 Words

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Histology Review Supplement Free Essays

string(74) " speed of conduction of electrical impulses along the length of the axon\." Histology Review Supplement The slides in this section are designed to provide a basic histology review related to topics introduced in the PhysioEx lab simulations and in your anatomy and physiology textbook. From the PhysioEx main menu, select Histology Tutorial. The opening screen should appear after a few seconds. We will write a custom essay sample on Histology Review Supplement or any similar topic only for you Order Now The Sort by menu is located at the top left. Click on the white drop-down menu and select â€Å"Histology Review† from the list. You will note that the slides in the histology module are grouped in the following folders: Skeletal muscle slides Nervous tissue slides Endocrine tissue slides Cardiovascular tissue slides Respiratory tissue slides Digestive tissue slides Renal tissue slides Select the group of slides you wish to view, and then refer to the relevant worksheet in this section for a step-by-step tutorial. For example, if you would like to review the skeletal muscle slides, click on the Skeletal muscle slides folder, and then turn to the next page of this lab manual for the worksheet entitled Skeletal Muscle Tissue Review to begin your review. You will have the option of viewing slides with or without labels by clicking the On/Off buttons at the bottom left of the viewer. Since the slides in this module have been selected for their relevance to topics covered in the PhysioEx lab simulation, it is recommended that you complete the worksheets along with a related PhysioEx lab. For example, you might complete the Skeletal Muscle Tissue worksheet right before or after your instructor assigns you Exercise 2, the PhysioEx lab simulation on Skeletal Muscle Physiology. For additional histology review, turn to page 121. 23 Skeletal Muscle Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Skeletal muscle slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Click slide 1. Skeletal muscle is composed of extremely large, cylindrical multinucleated cells called myofibers. The nuc lei of the skeletal muscle cell (myonuclei) are located peripherally just subjacent to the muscle cell plasmalemma (sarcolemma). The interior of the cell is literally filled with an assembly of contractile proteins (myofilaments) arranged in a specific overlapping pattern oriented parallel to the long axis of the cell. Click slides 2, 3. Sarcomeres are the functional units of skeletal muscle. The organization of contractile proteins into a regular end-to-end repeating pattern of sarcomeres along the length of each cell accounts for the striated, or striped, appearance of skeletal muscle in longitudinal section. Click slide 4. The smooth endoplasmic reticulum (sarcoplasmic reticulum), modified into an extensive network of membranous channels that store, release, and take up the calcium necessary for contraction, also functions to further organize the myofilaments inside the cell into cylindrical bundles called myofibrils. The stippled appearance of the cytoplasm in cells cut in cross section represents the internal organization of myofilaments bundled into myofibrils by the membranous sarcoplasmic reticulum. What is the functional unit of contraction in skeletal muscle? Click slide 5. The neural stimulus for contraction arises from the axon of a motor neuron whose axon terminal comes into close apposition to the muscle cell sarcolemma. Would you characterize skeletal muscle as voluntary or involuntary? Name the site of close juxtaposition of an axon terminal with the muscle cell plasmalemma. Skeletal muscle also has an extensive connective tissue component that, in addition to conducting blood vessels and nerves, becomes continuous with the connective tissue of its tendon. The tendon in turn is directly continuous with the connective tissue covering (the periosteum) of the adjacent bone. This connective tissue continuity from muscle to tendon to bone is the basis for movement of the musculoskeletal system. What is the name of the loose areolar connective tissue covering of an individual muscle fiber? endomysium The perimysium is a collagenous connective tissue layer that groups several muscle fibers together into bundles called fascicles . the sacromeres What are the two principal contractile proteins that compose the functional unit of contraction? Which connective tissue layer surrounds the entire muscle and merges with the connective tissue of tendons and aponeuroses? epimysium actin and myosin What is the specific relationship of the functional unit of contraction to the striated appearance of a skeletal muscle fiber? the repeating pattern of the sacromeres organized end to end 124 Histology Review Supplement Nervous Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Nervous tissue slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Nervous tissue is composed of nerve cells (neurons) and a variety of support cells. Click slide 1. Each nerve cell consists of a cell body (perikaryon) and one or more cellular processes (axon and dendrites) extending from it. The cell body contains the nucleus, which is typically pale-staining and round or spherical in shape, and the usual assortment of cytoplasmic organelles. Characteristically, the nucleus features a prominent nucleolus often described as resembling the upil of a bird’s eye (â€Å"bird’s eye,† or â€Å"owl’s eye,† nucleolus). Click slide 2. The cytoplasm of the cell body is most often granular in appearance due to the presence of darkly stained clumps of ribosomes and rough endoplasmic reticulum (Nissl bodies/ Nissl substance). Generally, a single axon arises from the cell body at a pale-staining region (axon hillock), devoid of Nissl b odies. The location and number of dendrites arising from the cell body varies greatly. Axons and dendrites are grouped together in the peripheral nervous system (PNS) to form peripheral nerves. What is the primary unit of function in nervous tissue? Click slide 5. Because Schwann cells are aligned in series and myelinate only a small segment of a single axon, small gaps occur between the myelin sheaths of adjacent contiguous Schwann cells. The gaps, called nodes of Ranvier, together with the insulating properties of myelin, enhance the speed of conduction of electrical impulses along the length of the axon. You read "Histology Review Supplement" in category "Papers" Different support cells and myelinating cells are present in the central nervous system (CNS). What is the general name for all support cells within the CNS? neuroglial cells Name the specific myelinating cell of the CNS. Oligodendrocyte In the PNS, connective tissue also plays a role in providing support and organization. In fact, the composition and organization of the connective tissue investments of peripheral nerves are similar to those of skeletal muscle. Click slide 3. Each individual axon or dendrite is surrounded by a thin and delicate layer of loose connective tissue called the endoneurium (not shown. ) The perineurium, a slightly thicker layer of loose connective tissue, groups many axons and dendrites together into bundles (fascicles). The outermost epineurium surrounds the entire nerve with a thick layer of dense irregular connective tissue, often infiltrated with adipose tissue, that conveys blood and lymphatic vessels to the nerve. There is no connective tissue component within the nervous tissue of the CNS. What is the relationship of the endoneurium to the myelin sheath? neuron Name the pale-staining region of the cell body from which the axon arises. nucleus The support cells of the nervous system perform extremely important functions including support, protection, insulation, and maintenance and regulation of the microenvironment that surrounds the nerve cells. Click slides 3, 4. In the PNS, support cells surround cell bodies (satellite cells) and individual axons and dendrites (Schwann cells). Schwann cells, in particular, are responsible for wrapping their cell membrane jelly-roll style around axons and dendrites to form an insulating sleeve called the myelin sheath. enclosed and protects Histology Review Supplement 125 Endocrine Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Endocrine tissue slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. antrum, except for a thin rim of granulosa cells (corona radiata) that encircles the oocyte and a pedestal of granulosa cells (cumulus oophorus) that attaches the oocyte to the inner wall of the antrum. Which cells of the ovarian follicle secrete estrogen? Thyroid Gland The thyroid gland regulates metabolism by regulating the secretion of the hormones T3 (triiodothyronine) and T4 (thyroxine) into the blood. Click slide 1. The gland is composed of fluid-filled (colloid) spheres, called follicles, formed by a simple epithelium that can be squamous to columnar depending upon the gland’s activity. The colloid stored in the follicles is primarily composed of a glycoprotein (thyroglobulin) that is synthesized and secreted by the follicular cells. Under the influence of the pituitary gland, the follicular cells take up the colloid, convert it into T3 and T4, and secrete the T3 and T4 into an extensive capillary network. A second population of cells, parafollicular (C) cells (not shown), may be found scattered through the follicular epithelium but often are present in the connective tissue between follicles. The pale-staining parafollicular cells secrete the protein hormone calcitonin. Why is the thyroid gland considered to be an endocrine organ? Uterus Click slides 4, 5, 6. The uterus is a hollow muscular organ with three major layers: the endometrium, myometrium, and either an adventitia or a serosa. The middle, myometrial layer of the uterine wall is composed of several layers of smooth muscle oriented in different planes. Click slide 6. The innermost (nearest the lumen) endometrial layer is further divided functionally into a superficial functional layer (stratum functionalis) and a deep basal layer (stratum basalis). Click slide 4. A simple columnar epithelium with both ciliated and nonciliated cells lines the surface of the endometrium. The endometrial connective tissue features an abundance of tubular endometrial glands that extend from the base to the surface of the layer. During the proliferative phase of the menstrual cycle, shown here, the endometrium becomes thicker as the glands and blood vessels proliferate. Click slide 5. In the secretory phase, the endometrium and its glands and blood vessels are fully expanded. Click slide 6. In the menstrual phase, the glands and blood vessels degenerate as the functional layer of the endometrium sloughs away. The deep basal layer (stratum basalis) is not sloughed and will regenerate the endometrium during the next proliferative phase. Which layer of the endometrium is shed during the menstrual phase of the menstrual cycle? it secrets a horomone What hormone secreted by the pituitary gland controls the synthesis and secretion of T3 and T4? TSH – thyroid stimulating hormone What is the function of calcitonin? causes CA to be released into blood Ovary The ovary is an organ that serves both an exocrine function in producing eggs (ova) and an endocrine function in secreting the hormones estrogen and progesterone. Click slide 2. Grossly, the ovary is divided into a peripherally located cortex in which the oocytes (precursors to the ovulated egg) develop and a central medulla in which connective tissue surrounds blood vessels, lymphatic vessels and nerves. The oocytes, together with supporting cells (granulosa cells), form the ovarian follicles seen in the cortex at various stages of development. Click slide 3. As an individual oocyte grows, granulosa cells proliferate from a single layer of cuboidal cells that surround the oocyte to a multicellular layer that defines a fluid-filled spherical follicle. In a mature follicle (Graafian follicle), the granulosa cells are displaced to the periphery of the fluid-filled 126 Histology Review Supplement endometrium What is the function of the deep basal layer (stratum basalis) of the endometrium? regenerate new superficial layer What composes a serosa? perimetrium How does the serosa of the uterus, where present, differ from visceral peritoneum? location Pancreas The pancreas is both an endocrine and an exocrine gland. Click slide 7. The exocrine portion is characterized by glandular secretory units (acini) formed by a simple epithelium of triangular or pyramidal cells that encircle a small central lumen. The central lumen is the direct connection to the duct system that conveys the exocrine secretions out of the gland. Scattered among the exocrine secretory units are the pale-staining clusters of cells that compose the endocrine portion of the gland. The cells that form these clusters, called pancreatic islet cells (islets of Langerhans), secrete a number of hormones, including insulin and glucagon. Do the pancreatic islets secrete their hormones into the same duct system used by the exocrine secretory cells? no, but directly into blood stream Histology Review Supplement 127 Cardiovascular Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Cardiovascular Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Which component of the intercalated disc is a junction that provides the intercellular communication required for the myocardium to perform as a functional syncytium? gap juntions Blood Vessels Blood vessels form a system of conduits through which lifesustaining blood is conveyed from the heart to all parts of the body and back to the heart again. Click slide 3. Generally, the wall of every vessel is described as being composed of three layers, or tunics. The tunica intima, or tunica interna, a simple squamous endothelium and a small amount of subjacent loose connective tissue, is the innermost layer adjacent to the vessel lumen. Smooth muscle and elastin are the predominant constituents of the middle tunica media, and the outermost tunica adventitia, or tunica externa, is a connective tissue layer of variable thickness that provides support and transmits smaller blood and lymphatic vessels and nerves. The thickness of each tunic varies widely with location and function of the vessel. Arteries, subjected to considerable pressure fluctuations, have thicker walls overall, with the tunica media being thicker than the tunica adventitia. Veins, in contrast, are subjected to much lower pressures and have thinner walls overall, with the tunica adventitia often outsizing the tunica media. Because thin-walled veins conduct blood back to the heart against gravity, valves (not present in arteries) also are present at intervals to prevent backflow. In capillaries, where exchange occurs between the blood and tissues, the tunica intima alone composes the vessel wall. The tunica media of the aorta would have a much greater proportion of what type of tissue than a small artery? Heart The heart is a four-chambered muscular pump. Although its wall can be divided into three distinct histological layers (endocardium, myocardium, and epicardium), the cardiac muscle of the myocardium composes the bulk of the heart wall. Click slide 1. Contractile cardiac muscle cells (myocytes, myofibers) have the same striated appearance as skeletal muscle, but are branched rather than cylindrical in shape and have one (occasionally two) nucleus (myonucleus) rather than many. The cytoplasmic striations represent the same organization of myofilaments (sarcomeres) and alignment of sarcomeres as in skeletal muscle, and the mechanism of contraction is the same. The intercalated disc, however, is a feature unique to cardiac muscle. The densely stained structure is a complex of intercellular junctions (desmosomes, gap junctions, fasciae adherens) that structurally and functionally link cardiac muscle cells end to end. A second population of cells in the myocardium composes the noncontractile intrinsic conduction system (nodal system). Although cardiac muscle is autorhythmic, meaning it has the ability to contract involuntarily in the absence of extrinsic innervation provided by the nervous system, it is the intrinsic conduction system that prescribes the rate and orderly sequence of contraction. Extrinsic innervation only modulates the inherent activity. Click slide 2. Of the various components of the noncontractile intrinsic conduction system, Purkinje fibers are the most readily observed histologically. They are particularly abundant in the ventricular myocardium and are recognized by their very pale-staining cytoplasm and larger diameter. The connective tissue component of cardiac muscle is relatively sparse and lacks the organization present in skeletal muscle. Which component of the intercalated disc is a strong intercellular junction that functions to keep cells from being pulled apart during contraction? lastic fiber In general, which vessel would have a larger lumen, an artery or its corresponding vein? vein Why would the tunica media and tunica adventitia not be present in a capillary? to allow material exchange between blood and tissue desmosomes What is a functional syncytium? Because the cardiac muscle cells are mechanically, chemically, and electrically connecte d to one another, the entire tissue resembles a single, enormous muscle cell. 128 Histology Review Supplement Respiratory Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Respiratory Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. The respiratory system serves both to conduct oxygenated air deep into the lungs and to exchange oxygen and carbon dioxide between the air and the blood. The trachea, bronchi, and bronchioles are the part of the system of airways that conduct air into the lungs. Click slide 2. The trachea and bronchi are similar in morphology. Their lumens are lined by pseudostratified columnar ciliated epithelium with goblet cells (respiratory epithelium), underlain by a connective tissue lamina propria and a deeper connective tissue submucosa with coiled sero-mucous glands that open onto the surface lining of the airway lumen. Click slide 1. Deep to the submucosa are the hyaline cartilage rings that add structure to the wall of the airway and prevent its collapse. Peripheral to the cartilage is a connective tissue adventitia. The sero-mucous glands are also visible in this slide. Click slide 3. The bronchioles, in contrast, are much smaller in diameter with a continuous layer of smooth muscle in place of the cartilaginous reinforcements. A gradual decrease in the height of the epithelium to simple columnar also occurs as the bronchioles decrease in diameter. Distally the bronchioles give way to the respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli in which gas exchange occurs. In the respiratory bronchiole, the epithelium becomes simple cuboidal and the continuous smooth muscle layer is interrupted at intervals by the presence of alveoli inserted into the bronchiolar wall. Click slide 4. Although some exchange occurs in the respiratory bronchiole, it is within the alveoli of the alveolar ducts and sacs that the preponderance of gas exchange transpires. Here the walls of the alveoli, devoid of smooth muscle, are reduced in thickness to the thinnest possible juxtaposition of simple squamous alveolar cell to simple squamous capillary endothelial cell. What are the primary functions of the respiratory epithelium? What is the primary functional unit of the lung? alveoli The alveolar wall is very delicate and subject to collapse. Why is there no smooth muscle present in its wall for support? smooth muscle would hinder the gas exchange What are the three basic components of the air-blood barrier? alveolar, capillary walls and basal laminae humidfy, filter and warm incoming air Why doesn’t gas exchange occur in bronchi? bronchi have no alveoli Histology Review Supplement 129 Digestive Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Digestive Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. smooth muscle nearest the stomach, and a mix of both skeletal and smooth muscle in between. 4. The outermost layer of the esophagus is an adventitia for the portion of the esophagus in the thorax, and a serosa after the esophagus penetrates the diaphragm and enters the abdominal cavity. Click slide 3. Here we can see the abrupt change in epithelium at the gastroesophageal junction, where the esophagus becomes continuous with the stomach. Briefly explain the difference between an adventitia and a serosa. Salivary Gland The digestive process begins in the mouth with the physical breakdown of food by mastication. At the same time salivary gland secretions moisten the food and begin to hydrolyze carbohydrates. The saliva that enters the mouth is a mix of serous secretions and mucus (mucin) produced by the three major pairs of salivary glands. Click slide 1. The secretory units of the salivary tissue shown here are composed predominantly of clusters of pale-staining mucussecreting cells. More darkly stained serous cells cluster to form a demilune (half moon) adjacent to the lumen and contribute a clear fluid to the salivary secretion. Salivary secretions flow to the mouth from the respective glands through a well-developed duct system. Are salivary glands endocrine or exocrine glands? serosa secret serous fluid, and adventitia don’t. Stomach The wall of the stomach has the same basic four-layered organization as that of the esophagus. Click slide 4. The mucosa of the stomach consists of a simple columnar epithelium, a thin connective tissue lamina propria, and a thin muscularis mucosa. The most significant feature of the stomach mucosa is that the epithelium invaginates deeply into the lamina propria to form superficial gastric pits and deeper gastric glands. Although the epithelium of the stomach is composed of a variety of cell types, each with a unique and important function, only three are mentioned here (see slide 5). Click slide 5. The surface mucous cells are simple columnar cells that line the gastric pits and secrete mucus continuously onto the surface of the epithelium. The large round pink- to red-stained parietal cells that secrete hydrochloric acid (HCl) line the upper half of the gastric glands; more abundant in the lower half of the gastric glands are the chief cells (not shown), usually stained blue, that secrete pepsinogen (a precursor to pepsin). Click slide 4. The submucosa is similar to that of the esophagus but without glands. The muscularis externa has the two typical circumferential and longitudinal layers of smooth muscle, plus an extra layer of smooth muscle oriented obliquely. The stomach’s outermost layer is a serosa. What is the function of the mucus secreted by surface mucous cells? exocrine Which salivary secretion, mucous or serous, is more thin and watery in consistency? serous Esophagus Through contractions of its muscular wall (peristalsis), the esophagus propels food from the mouth to the stomach. Four major layers are apparent when the wall of the esophagus is cut in transverse section: Click slide 2. 1. The mucosa adjacent to the lumen consists of a nonkeratinized stratified squamous epithelium, its immediately subjacent connective tissue (lamina propria) containing blood vessels, nerves, lymphatic vessels, and cells of the immune system, and a thin smooth muscle layer (muscularis mucosa) forms the boundary between the mucosa and the submucosa. Because this slide is a low magnification view, it is not possible to discern all parts of the mucosa nor the boundary between it and the submucosa. 2. The submucosa is a layer of connective tissue of variable density, traversed by larger caliber vessels and nerves, that houses the mucus-secreting esophageal glands whose secretions protect the epithelium and further lubricate the passing food bolus. 3. Much of the substance of the esophageal wall consists of both circumferentially and longitudinally oriented layers of muscle called the muscularis externa. The muscularis externa is composed of skeletal muscle nearest the mouth, 130 Histology Review Supplement protects the epithelium Small Intestine The key to understanding the histology of the small intestine lies in knowing that its major function is absorption. To that end, its absorptive surface area has been amplified greatly in the following ways: 1. The mucosa and submucosa are thrown into permanent folds (plicae circulares). 2. Fingerlike extensions of the lamina propria form villi (singular: villus) that protrude into the intestinal lumen (click slide 7). 3. The individual simple columnar epithelial cells (enterocytes) that cover the villi have microvilli (a brush border), tiny projections of apical plasma membrane to increase their absorptive surface area (click slide 6). Click slide 7. Although all three segments of the small intestine (duodenum, jejunum, and ileum) possess villi and tubular crypts of Lieberkuhn that project deep into the mucosa between villi, some unique features are present in particular segments. For example, large mucous glands (duodenal glands, Brunner’s glands) are present in the submucosa of the duodenum. In addition, permanent aggregates of lymphatic tissue (Peyer’s patches) are a unique characteristic of the ileum (click slide 8). Aside from these specific features and the fact that the height of the villi vary from quite tall in the duodenum to fairly short in the terminal ileum, the overall morphology of mucosa, submucosa, muscularis externa, and serosa is quite similar in all three segments. Why is it important for the duodenum to add large quantities of mucus (from the duodenal glands) to the partially digested food entering it from the stomach? Click slide 10. Located in the surrounding connective tissue, roughly at the points of the hexagon where three lobules meet, is the portal triad (portal canal). Click slide 12. The three constituents of the portal triad include a branch of the hepatic artery, a branch of the hepatic portal vein, and a bile duct. Both the hepatic artery and portal vein empty their oxygen-rich blood and nutrient-rich blood, respectively, into the sinusoids. This blood mixes in the sinusoids and flows centrally in between and around the hepatocytes toward the central vein. Bile, produced by hepatocytes, is secreted into very small channels (bile canaliculi) and flows peripherally (away from the central vein) to the bile duct. Thus, the flow of blood is from peripheral to central in a hepatic lobule, while the bile flow is from central to peripheral. What general type of cell is the phagocytic Kupffer cell? immune Blood in the portal vein flows directly from what organs? liver What is the function of bile in the digestive process? protects intestinal walls raises alkalinity to create ideal pH Colon Click slide 9. The four-layered organization is maintained in the wall of the colon, but the colon has no villi, only crypts of Lieberkuhn. Simple columnar epithelial cells (enterocytes with microvilli) are present to absorb water from the digested food mass, and the numbers of mucous goblet cells are increased substantially, especially toward the distal end of the colon. Why is it important to have an abundance of mucous goblet cells in the colon? because they secrete mucous, which is important to fascilitate degestion Pancreas Click slide 13. The exocrine portion of the pancreas synthesizes and secretes pancreatic enzymes. The individual exocrine secretory unit, or acinus, is formed by a group of pyramidal-shaped pancreatic acinar cells clustered around a central lumen into which they secrete their products. A system of pancreatic ducts then transports the enzymes to the duodenum where they are added to the lumen contents to further aid digestion. The groups of pale-staining cells are the endocrine pancreatic islet (islets of Langerhans) cells. Liver The functional tissue of the liver is organized into hexagonally shaped cylindrical lobules, each delineated by connective tissue. Click slide 11. Within the lobule, large rounded hepatocytes form linear cords that radiate peripherally from the center of the lobule at the central vein to the surrounding connective tissue. Blood sinusoids lined by simple squamous endothelial cells and darkly stained phagocytic Kupffer cells are interposed between cords of hepatocytes in the same radiating pattern. Histology Review Supplement 131 Renal Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Renal Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. The many functions of the kidney include filtration, absorption, and secretion. The kidney filters the blood of metabolic wastes, water, and electrolytes and reabsorbs most of the water and sodium ions filtered to regulate and maintain the body’s fluid volume and electrolyte balance. The kidney also plays an endocrine role in secreting compounds that increase blood pressure and stimulate red blood cell production. The uriniferous tubule is the functional unit of the kidney. It consists of two components: the nephron to filter and the collecting tubules and ducts to carry away the filtrate. Click slide 1. The nephron itself consists of the renal corpuscle, an intimate association of the glomerular capillaries (glomerulus) with the cup-shaped Bowman’s capsule, and a single elongated renal tubule consisting of segments regionally and sequentially named the proximal convoluted tubule (PCT), the descending and ascending segments of the loop of Henle, and the distal convoluted tubule (DCT). Click slide 2. A closer look at the renal corpuscle shows both the simple squamous epithelium of the outer layer (parietal layer) of the glomerular capsule (Bowman’s capsule) and the specialized inner layer (visceral layer) of podocytes that extend footlike processes to completely envelop the capillaries of the renal glomerulus. Processes of adjacent podocytes interdigitate with one another, leaving only small slits (filtration slits) between the processes through which fluid from the blood is filtered. The filtrate then flows into the urinary space that is directly continuous with the first segment of the renal tubule, the PCT. The PCT is lined by robust cuboidal cells equipped with microvilli to greatly increase the surface area of the side of the cell facing the lumen. Click slide 3. In the loop of Henle, lining cells are simple squamous to simple cuboidal. The DCT cells are also simple cuboidal but are usually much smaller than those of the PCT. The sparse distribution of microvilli, if present at all, on the cells of the DCT relates to their lesser role in absorption. The DCT is continuous directly with the collecting tubules and collecting ducts that drain the filtrate out of the kidney. The large renal artery and its many subdivisions provide an abundant blood supply to the kidney. The smallest distal branches of the renal artery become the afferent arterioles that directly supply the capillaries of the glomerulus. In a unique situation, blood from the glomerular capillaries passes into the efferent arteriole rather than into a venule. The efferent arteriole then perfuses two more capillary beds, the peritubular capillary bed and vasa recta that provide nutrient blood to the kidney tissue itself, before ultimately draining into the renal venous system. In which segment of the renal tubule does roughly 75–80% of reabsorption occur? proximal convoluted tubules How are proximal convoluted tubule (PCT) cells similar to enterocytes of the small intestine? both absorb water, salts, vitamins, phosphates Starting from inside the glomerular capillary through to the urinary space, what are the three layers through which the filtrate must pass? glomerular capillary enothelium, glomrular basement membrane visceral layer of bowman’s capsule Under normal circumstances in a healthy individual, would red blood cells or any other cells be present in the renal filtrate? no In addition to providing nutrients to the kidney tubules, what is one other function of the capillaries in the peritubular capillary bed? they deliver blood to tubular sites 132 Histology Review Supplement How to cite Histology Review Supplement, Papers

Nobel Prize Assignment Essay Example

Nobel Prize Assignment Essay Nobel Prize Founded by Alfred Nobel, the Nobel Prize is awarded to candidates in the fields of physics, chemistry, medicine or physiology, literature, economic sciences, and peace every year since 1901 – except for economic sciences, which was introduced as a Nobel Prize in 1968 by the Sveriges Riksbank. On account of World War I and II, the Nobel Prize was not awarded only on nine occasions since the established year from 1901. Alfred Nobel, a Swedish engineer, chemist, and philanthropist, created a will that would bequeath 94% of his assets into a series of prizes for those who contribute the highest benefit to mankind in the respective fields. Recipients of the Nobel Prize – which can be shared by no more than three people and can also be awarded posthumously in certain cases – receive a medal, sum of money, and diploma for their achievements and are elected by the Nobel Foundation. The Nobel Foundation was created by the executors of Nobel’s will, Rudolf Liljequist and Ragnar Sohlman. The private organization that is the Nobel Foundation is also responsible for administrative details and finances of the prizes. The prizes are presented according to their respective field. The Royal Swedish Academy of the Sciences awards the prizes for chemistry, physics, and economic sciences. The Swedish Academy presents the Nobel Prize in literature. The prize for physiology or medicine is awarded by the National Assembly at Karolinska Institutet. We will write a custom essay sample on Nobel Prize Assignment specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Nobel Prize Assignment specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Nobel Prize Assignment specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Finally, the award for peace is presented by the Norwegian Nobel Committee and is the only award to be presented in Norway rather than in Sweden. All prizes are awarded based upon several factors but mainly through Nobel’s maxim of delivering the greatest benefit to mankind and is ultimately decided by the Nobel Committees. One hundred and three Nobel Prizes in medicine or physiology have been awarded since 1901 and two-hundred one individuals are known as laureates in the field since the prize may be shared by three or more people. Around forty-three awards for the Nobel Prize in medicine and physiology have been presented relating to the field of neuroscience, such as Roger Guillemin in 1977 for his research in the production of peptides in the brain and Roger Wolcott Sperry in 1981 for research into the functions of the right and left hemispheres of the brain. Other rewarded scientists for the Nobel Prize in medicine or physiology include Nikolaas Tinbergen, Konrad Zacharias Lorenz, nd Karl von Frisch for their research into ethology, a scientific enquiry into animal behavior. Scientists whose research affected the understanding of Parkinson’s disease include Arvid Carlsson and Paul Greengard. The two were awarded in the year 2000 mainly for their neurological research into signal transduction in the nervous system. Carlsson and Greengard’s colleague, Kandel, who also shared the prize with them that year, was rewarded for his studies in synaptic function; more precisely, a closer look into short term and long term memory. Specifically, Arvid Carlsson and Paul Greengard’s research affected the progression of understanding of Parkinson’s disease by showing how important neurotransmitters such as dopamine work and affect the function of the brain and thus the human body. Carlsson more specifically identified dopamine and Greengard portrayed how neurotransmitters like dopamine, noradrenaline, and serotonin are able to exert their effects. His research includes a type of signal transmission called the slow synaptic transmission. Carleton Gajdusek’s research in 1976 on the first human prion disease named kuru later on would also help Stanley Prusiner’s studies in 1997 for his work on prions which would shed more light into dementia-related diseases such as Alzheimer’s disease. Although prions are reflective in diseases such as Creutzfeldt–Jakob disease or kuru, Prusiner’s work opens a new understanding of the pathogenesis of diseases like Alzheimer’s via the suggestions of non-prion proteins mutating to facilitate dangerous deposits in the brain. Swedish scientist and Nobel laureate Arvid Carlsson was able to show the importance of dopamine as a neurotransmitter in the brain. By developing an assay that allowed him to measure dopamine at an extremely sensitive level in the brain tissues, Carlsson found that dopamine is concentrated in other parts of the brain – specifically the basal ganglia, the part of the brain located in the forebrain and connected with the cerebral cortex. Contrary to belief at his time that dopamine is merely a precursor to a neurotransmitter named norepinephrine; Carlsson concluded that dopamine in and of itself is able to act as a neurotransmitter and is greatly vital for the ability to control fine motor movements. Carlsson then led to a series of experiments where he utilized a plant substance named reserpine to discover the importance of dopamine for movement. Carlsson administered reserpine to nimals thus decreasing their levels of dopamine which ultimately caused a loss of movement control. The effect of reserpine on the animals showed symptoms akin to Parkinson’s disease in humans. Carlsson then proceeded to treat the animals with levodopa (L-dopa), a precursor to dopamine, a substance that the brain converts into dopamine and is used in lieu of mere dopamine in order to prevent side effects of dopamine in the blood and since dopamine cannot cross the blood-brain barrier in the first place. Eventually, Carlsson found that the animal’s symptoms disappeared and returned to their previous, normal state since the levels of dopamine in the brain were normalized. Thus, Carlsson’s findings led to more findings that Parkinson’s disease patients have unusually low levels of dopamine represented in the basal ganglia, an area that is very important in the control of muscle movements. There has also been evidence provided by Carlsson of forms of mental illness associated with unsteady levels of dopamine. Carlsson’s findings essentially explain the tremor, rigidity, and decreased motor function associated with Parkinson’s disease since patients with Parkinson’s share the malfunction of certain nerve cells within the basal ganglia that creates dopamine. Conclusively, the animals treated with reserpine and patients with Parkinson’s are low on dopamine levels. Nowadays, the same treatment of levodopa that Carlsson used for treating the symptoms of the reserpine in the animals has been tweaked for human use as a primary pharmaceutical option for patients with Parkinson’s disease in order to alleviate the symptoms. By allowing dopamine levels to be controlled through levodopa therapy, patients are able to experience more stable amounts of dopamine in their system, as opposed to having an irregularly low amount, so that one the ongoing loss of fine motor control associated with the onset of Parkinson’s disease may be alleviated for some time. Besides Parkinson’s disease, Carlsson’s Nobel worthy research has also increased the understanding of several other drugs. Carlsson is also notable for his contribution into the discovery and a new generation of drugs, the selective serotonin uptake inhibitors, to treat depression or personality disorders. This new class of drugs is now known as SSRI’s and is considered for many patients dealing with depression. For antipsychotic drugs used to treat schizophrenia, Carlsson showed that the drugs affect the signal transmission of dopamine by blocking the dopamine receptors. Nonetheless, by proving the popular belief of dopamine at his time that dopamine is simply a precursor to another neurotransmitter wrong and showing dopamine’s unknown importance at the time, Arvid Carlsson’s findings essentially lead the development of levodopa and consequently has helped an innumerable amount of patients dealing with the motor symptoms associated with Parkinson’s disease. Although not a cure, Carlsson’s work has been a stepping stone for understanding Parkinson’s disease and has eased the discomforts of such a deadly disease that affects many people in the world.